Kleborate
Klebsiella comprehensive AMR and typing analysis software.
Current Kleborate version: v2.2.0.
For a detailed explanation about the Kleborate tool and outputs in general, please view their documentation at: http://bit.ly/kleborate-workshop.
The Kleborate software from Holt et al provides in depth species, ST, virulence genes, capsule typing and antimicrobial resistance prediction for Klebsiella. Results are displayed in the Genome Report and in the "Typing" table of the Collection View, and can be downloaded from both download menus.
Kleborate is focussed on the Klebsiella pneumoniae complex (KpSC). Typing and inexact virulence locus results for Klebsiella species outside of this complex should be treated with care.
The Kleborate output splits into four main sections:
- 1.
- 2.
- 3.
- 4.
- Yersiniabactin/YbST
- Colibactin/CbST
- Aerobactin/AbST
- Salmochelin/SmST
- RmpA, RmpA2 (hypermucoidy)
Kleborate AMR profiles and determinants are displayed in the genome reports and collection views. The following antimicrobials are classified by Kleborate.
Kleborate column | Pathogenwatch Antimicrobial Name |
---|---|
AGly_acquired | Aminoglycosides |
Col_acquired | Colistin |
Col_mutations | Colistin |
Fcyn_acquired | Fosfomycin |
Flq_acquired | Fluoroquinolones |
Flq_mutations | Fluoroquinolones |
Gly_acquired | Glycopeptides |
MLS_acquired | Macrolides |
Phe_acquired | Phenicols |
Rif_acquired | Rifampicin |
Sul_acquired | Sulfonamides |
Tet_acquired | Tetracycline |
Tgc_acquired | Tigecycline |
Tmt_acquired | Trimethoprim |
Bla_chr | Beta-Lactams |
Bla_mutations | Beta-Lactams |
Bla_inhR_acquired | Beta-lactams+Inhibitors |
Bla_ESBL_acquired | ESBLs |
Bla_ESBL_acquired_inhR | ESBLs+Inhibitors |
Bla_Carb_acquired | Carbapenems |
SHV | Other |
Omp | OmpK35/OmpK36 |
For a detailed description of the Kleborate and its output, we recommend visiting https://github.com/katholt/Kleborate/wiki. If you use the results of Kleborate in your publications or on the web please cite the version (provided in the CSV file download or at the top of this page) and the Kleborate publication. If you use the Kaptive K/O antigen assignments, please also cite the associated paper(s).
Last modified 4mo ago